The Application of Noninvasive Headspace Analysis to Media Fill Inspection

The Application of Noninvasive Headspace Analysis to Media Fill Inspection
ABSTRACT: The results of a proof-of-principle study demonstrating a new analytical technique for detecting microbial growth directly in pharmaceutical containers are described. This analytical technique, laser-based headspace analysis, uses tunable diode laser absorption spectroscopy to nondestructively determine gas concentrations in the headspace of a media-filled pharmaceutical container.