Oxygen Headspace Analysis for Air Headspace to Develop and Validate Container Closure Integrity Methods
Abstract
Container closure integrity testing (CCIT) by laser-based headspace oxygen can be performed for samples with an air headspace for the detection of both small (≤20 micron) and large (0.5-2 mm) defects, evaluating the container closure integrity (CCI) of a sample at any point in the product-package life cycle. This article will discuss developing and validating a CCI method using oxygen headspace analysis for air headspace samples, including considerations for different container sizes and fill volumes.
